Education
- Ph.D., Chemical Engineering. Rice University. 1995
- Dip. Eng., Chemical Engineering. National Technical University of Athens, Greece. 1989
Research Interests
The vascular system represents an exquisite feat of bioengineering. Fluid (blood) flow and mass transfer are intimately integrated with and actively regulate vascular cell responses. Elucidating the molecular nature of cellular processes in the dynamic setting of the vasculature therefore requires the synthesis of engineering principles with quantitative modeling, and concepts from biochemistry and molecular cell biology. My research in Molecular and Cellular Bioengineering is directed at developing a mechanistic understanding of the effects of shear stress due to fluid flow on gene regulation and receptor-mediated cell-cell interactions pertinent to cancer metastasis and inflammation/infection, two of the most critical pathological processes affecting mankind. The ultimate goal of my research program is to develop molecular therapies to combat these disorders using a directed multi-disciplinary approach.
Publications
- S.L. Napier, Z.R. Healy, R.L. Schnaar, K. Konstantopoulos, "Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells: The Roles of CD44v and Alternate Sialofucosylated Selectin Ligands", Journal of Biological Chemistry 282(6); 3433-3441, 2007.
- Z.R. Healy, N.H. Lee, M. Goldring, P. Talalay, T.W. Kensler, and K. Konstantopoulos, "Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-talk among COX-2, the Phase 2 Response and Apoptosis", Proceedings of the National Academy of Sciences USA 102(39); 14010-14015, 2005.
- S. Jadhav, C.D. Eggleton, and K. Konstantopoulos, "A 3D Computational Model Predicts that Cell Deformation Affects Receptor-Ligand Bond Lifetime and the Number of Bonds During Rolling Under Shear", Biophysical Journal 88(1); 96-104, 2005.
- W.D. Hanley, D. Wirtz, K. Konstantopoulos, "Distinct Kinetic and Mechanical Properties Govern Selectin-Leukocyte Interactions", Journal of Cell Science 117(12); 2503-2511, 2004.
- P. Pawar, P.K. Shin, S.A. Mousa, J.M. Ross, and K. Konstantopoulos, "Fluid Shear Regulates the Kinetics and Receptor Specificity of Staphylococcus Aureus Binding to Activated Platelets", Journal of Immunology 173(2); 1258-1265, 2004.
|
