Whiting School of Engineering




The Department of Chemical and Biomolecular Engineering

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Justin Hanes

Professor


Office: (410) 516-3484
Email: hanes@jhu.edu

Education

  • B.S., Chemical Engineering, University of California Los Angeles, 1991.
  • Ph.D., Chemical Engineering, Massachusetts Institute of Technology, 1996.

Research Interests

Dr. Hanes’ research aims to develop the fundamental and applied knowledge needed to create biomaterial-based nanoparticles that efficiently deliver bioactive molecules to specific sites in the body, particularly through mucosal barriers (e.g., in the lungs) or via the blood. His group uses state-of-the-art biophysical tools, including high-resolution particle tracking techniques, to quantify the nanoscopic movements of hundreds of individual polymeric drug and gene nanocarriers in complex biological environments, such as mucus and inside live cells. This information is used to determine the rheological properties of complex biofluids at the micro-, meso- and bulk-scales, as well as to identify bottlenecks to efficient drug and gene delivery in various environments. Recently, there were at least ten products in clinical or preclinical trials in the US based on Dr. Hanes’ and his colleagues’ drug delivery inventions..

Publications

  • Lai SK, O'Hanlon ED, Harrold S, Man ST, Wang YY, Cone R, Hanes J. (2007) Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. P Natl Acad Sci USA, 104 (5): 1482-1487.
  • Lai SK, Hida K, Man ST, Chen C, Machamer C, Schroer TA, Hanes J. (2007) Privileged Delivery of Polymer Nanoparticles to the Perinuclear Region of Live Cells via a Non-Clathrin, Non-Degradative Pathway. Biomaterials, 28: 2876-2884.
  • Suk JS, Suh J, Lai SK, Hanes J, (2007) Quantitative comparison of the real-time transport of viral and nonviral gene vectors in primary neurons, Experimental Biology and Medicine, 232:461-469.
  • JS, Suh J, Choy K, Lai S, Fu J, and Hanes J (2006) Gene delivery to neurotypic cells with RGD and HIV-1 Tat peptide functionalized polymeric gene vectors, Biomaterials, 27:5143-5150.
  • Suh J, Dawson M, Hanes J (2005) Real-time particle tracking: Applications to drug and gene delivery, Adv Drug Del Rev, 57:63-78.