Drug Delivery, Biomaterials, & Tissue Engineering
The Chemical and Biomolecular Engineering faculty at The Johns Hopkins University is at the forefront of drug delivery, tissue, and biomaterials research and discovery. Research on the design, synthesis, and characterization of advanced biomaterials is currently being conducted in diverse areas, including:
- Cancer detection, therapy and prevention.
- Biomaterial-cell interactions in applications such as tissue engineering, advanced stem-cell culture, biosensors, and targeted drug delivery via the blood.
- Advanced drug delivery, ranging from polymeric aerosols that carry life-saving drugs to cationic polymer/DNA self-assembled nanocomplexes that deliver DNA to specific tissues for in vivo gene therapy.
- Genetically-engineered polymers for tissue engineering and drug delivery applications.
- Cellular biopolymers and their role in cell migration and cancer metastasis.
Representative Images
Participating Faculty
Justin Hanes
Sharon Gerecht
David Gracias
Konstantinos Konstantopoulos
Denis Wirtz
Affiliates:
Shyam Biswal: School of Public Health, JHU
Jennifer Elisseeff: Biomedical Engineering, JHU
Kevin Yarema: Biomedical Engineering, JHU
Michael Yu: Materials Science & Engineering , JHU
Representative Publications
- "3D Lithographically Fabricated Nanoliter Containers for Drug Delivery",C. L. Randall, T. G. Leong, N. Bassik and D. H. Gracias, Advanced Drug Delivery Reviews 59, (15), 1547-1561 (2007). [Featured on the Cover].
- "Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells". Gerecht S, Burdick JA, Ferreira LS, Townsend SA, Langer R, and Vunjak-Novakovic G. Proceedings of National Academy of Sciences. 104:11298-11303 (2007).
- "Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix",P. Panorchan, J.S.H. Lee, T.P. Kole, Y. Tseng, and D. Wirtz, Biophysical Journal 91: 3499-3507 (2006).
- "Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus", S. K. Lai, D. E. O’Hanlon, S. Harrold, S. T. Man, Y. Y. Wang, R. Cone and J. Hanes, Proceedings of National Academy of Sciences 104(5):1482-1487 (2007).
