Cell & Molecular Biotechnology
Cell & Molecular Biotechnology takes advantage of Hopkins' world-renowned strengths in the biological sciences and medicine, and its proximity to several major national research centers. Our faculty collaborate with research groups from other departments and institutions as well as biotechnology companies in the Baltimore-Washington area. Faculty research interests encompass areas in genomic and protein engineering, smart nanosystems for organelle-specific delivery of therapeutics, stem cell research and cell engineering.
Representative Images
Participating Faculty
Michael Betenbaugh
Sharon Gerecht
Jeffrey Gray
Justin Hanes
Joseph Katz
Konstantinos Konstantopoulos
Marc Ostermeier
Denis Wirtz
Affiliates:
Shyam Biswal: School of Public Health, JHU
Jennifer Elisseeff: Biomedical Engineering, JHU
Jan Hoh: Physiology, JHU School of Medicine
Kevin Yarema: Biomedical Engineering, JHU
Representative Publications
- "Ballistic intracellular nanorheology reveals ROCK-hard stiffening response in to fluid flow", J.S.H. Lee, P. Panorchan, C.M. Hale, S.B. Khatau, Y. Tseng, and D. Wirtz, Journal of Cell Science 119: 1760-1768 (2006).
- "Directed evolution of protein switches and their application to the creation of ligand-binding proteins", Guntas, G., T. J. Mansell, J. R. Kim, and M. Ostermeier.Proceedings of the National Academy of Sciences USA 102, 11224-11229 (2005).
- "Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-talk among COX-2, the Phase 2 Response and Apoptosis", Z.R. Healy, N.H. Lee, M. Goldring, P. Talalay, T.W. Kensler, and Konstantinos Konstantopoulos, Proceedings of the National Academy of Sciences USA 102(39); 14010-14015, (2005).
- "Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway". S. K. Lai, K. Hida, S. T. Man, C. Chen, C. Machamer, T. A. Schroer and J. Hanes. Biomaterials 28: 2876-2884 (2007).
- "Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesis", A. Sivasubramanian, G. Chao, H.M. Pressler, K.D. Witrup, and J.J. Gray. Structure, vol. 14. 3 pp.401-414 (2006).
- "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells", Gerecht-Nir S, Dazard J-E, Golan-Mashiach M, Osenberg S, Botvinnik A, Amariglio N, Domany E, Rechavi G, Givol D and Itskovitz-Eldor J. Developmental Dynamics; 232:488-498 (2005).
